Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction
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چکیده
منابع مشابه
Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction.
Rats were subjected to one or two cycles of context fear conditioning and extinction to study the roles of the prelimbic cortex (PL) and infralimbic cortex (IL) in learning and relearning to inhibit fear responses. Inactivation of the PL depressed fear responses across the first or second extinction but did not impair learning or relearning fear inhibition (experiment 1). Inactivation of the IL...
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Behavioral flexibility, in the form of strategy switching or set shifting, helps animals cope with changing contingencies in familiar environments. The prelimbic (PL) and infralimbic (IL) regions of the rat prefrontal cortex (PFC) contribute to this ability so that rats trained to use one strategy have difficulty learning a new one if the PL/IL is inactivated. Thus, the PL/IL mediates learning ...
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ژورنال
عنوان ژورنال: Learning & Memory
سال: 2009
ISSN: 1072-0502
DOI: 10.1101/lm.1474609